LifesMiracle's
ingredients are among the most widely researched
in the nutrition industry. Below are the links to the most
recent published independent university studies on LifesMiracle's
ingredients
to validate safety and efficacy.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Acai (Euterpe oleracea mart.) top of page
Acai Berries Health Benefits WebMD examines the health benefits of the açai berries, known as a “superfood” because of their many health benefits, anti-aging properties, and weight loss claims. WebMD Medical Reference
Study at the University of Florida on the effect of Acai on cancer cells from the University of Florida Website
Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açaí) extracts in mesenteric vascular bed Rocha AP, Carvalho LC, Sousa MA, Madeira SV, Sousa PJ, Tano T, Schini-Kerth VB, Resende AC, Soares de Moura R. Vascul Pharmacol. 2007 Feb;46(2):97-104. Epub 2006 Sep 1.
Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (Acai). Schauss AG, Wu X, Prior RL, Ou B, Huang D, Owens J, Agarwal A, Jensen GS, Hart AN, Shanbrom E. J Agric Food Chem. 2006 Nov 1;54(22):8604-10.
Total oxidant scavenging capacities of Euterpe oleracea Mart. (Açaí) fruits. Lichtenthäler R, Rodrigues RB, Maia JG, Papagiannopoulos M, Fabricius H, Marx F. Int J Food Sci Nutr. 2005 Feb;56(1):53-64.
Bifidus (Bifidobacterium longum) top of page
The role of intestinal bifidobacteria on immune system development in laboratory animals. Dong P, Yang Y, Wang WP. Early Hum Dev. 2010 Jan 25. [Epub ahead of print] PMID: 20106610 [PubMed - as supplied by publisher]
A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. Gianotti L, Morelli L, Galbiati F, Rocchetti S, Coppola S, Beneduce A, Gilardini C, Zonenschain D, Nespoli A, Braga M. World J Gastroenterol. 2010 Jan 14;16(2):167-75. PMID: 20066735 [PubMed - in process]
Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight. Long RT, Zeng WS, Chen LY, Guo J, Lin YZ, Huang QS, Luo SQ. Int J Obes (Lond). 2010 Jan 12. [Epub ahead of print] PMID: 20065960 [PubMed - as supplied by publisher]
Impact of a synbiotic food on the gut microbial ecology and metabolic profiles. Vitali B, Ndagijimana M, Cruciani F, Carnevali P, Candela M, Guerzoni ME, Brigidi P. BMC Microbiol. 2010 Jan 7;10:4. PMID: 20055983 [PubMed - indexed for MEDLINE]
Bifidobacteria inhibit the inflammatory response induced by gliadins (celiac disease) in intestinal epithelial cells via modifications of toxic peptide generation during digestion. Laparra JM, Sanz Y. J Cell Biochem. 2010 Jan 5. [Epub ahead of print] PMID: 20052669 [PubMed - as supplied by publisher]
Pivotal Advance: Bifidobacteria and gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. De Palma G, Cinova J, Stepankova R, Tuckova L, Sanz Y. J Leukoc Biol. [Epub ahead of print] PMID: 20007908 [PubMed - as supplied by publisher]
Prevention of Escherichia coli O157:H7 infection in gnotobiotic mice associated with Bifidobacterium strains.Yoshimura K, Matsui T, Itoh K. Antonie Van Leeuwenhoek. 2010 Feb;97(2):107-17. Epub 2009 Nov 13. PMID: 19911297 [PubMed - in process]
Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice. Lee IA, Bae EA, Lee JH, Lee H, Ahn YT, Huh CS, Kim DH. Inflamm Res. 2009 Nov 1. [Epub ahead of print] PMID: 19882302 [PubMed - as supplied by publisher]
Body Mass Index (BMI) top of page
The BMI is a measure of your weight relative to your height. Combining this with information about your additional risk factors yields your risk for developing obesity-associated diseases and early death. Click here
Cha' De Bugre (Cordia salicifolia) top of page
Phytochemical investigation on leaf extract of Cordia salicifolia as an inhibitor of growth of Helicobacter pylori. Menghini L, Epifano F, Leporini L, Pagiotti R, Tirillini B. J Med Food. 2008 Mar;11(1):193-4. PMID: 18361757 [PubMed - indexed for MEDLINE]
Chlorella (Chlorella pyrenoidosa)
also
Chlorella Growth Factor (CGF
top of page
Examples of diets for infants and children's nutritional guidance, and their effects of adding Chlorella and CGF to food schedule, Tokuyasu, M., Tottori City, Japan: Conference proceedings at the nutritional Illness-Counseling Clinic, 1983. Japan Journal Nutrition, 1980, 1983, 41(5), pgs 275-283. The Japan Journal of Nutrition does not yet have a website so there's no link to this article.
Chlorella pyrenoidosa Supplementation Reduces the Risk of Anemia, Proteinuria and Edema in Pregnant Women. Nakano S, Takekoshi H, Nakano M. Plant Foods Hum Nutr. 2009 Dec 15. [Epub ahead of print] PMID: 20013055 [PubMed - as supplied by publisher]
Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk. Nakano S, Takekoshi H, Nakano M. J Med Food. 2007 Mar;10(1):134-42. PMID: 17472477 [PubMed - indexed for MEDLINE]
Decrease of heavy metal toxicity with chlorella. Shim JA, Son YA, Park JM, Kim MK. Nutr Res Pract. 2009 Spring;3(1):15-22. Epub 2009 Mar 31. PMID: 20016697 [PubMed - in process]
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa. Takekoshi H, Mizoguchi T, Komasa Y, Chubachi H, Inoue Y, Imanishi H, Nakano M. Oncol Rep. 2005 Aug;14(2):409-14. PMID: 16012723 [PubMed - indexed for MEDLINE]
Chlorella pyrenoidosa Prevents dyslipidemia and lowers the risk of heart disease in laboratory animals after chronic high fat diet treatment. Cherng JY, Shih MF. Life Sci. 2005 May 13;76(26):3001-13. PMID: 15850594 [PubMed - indexed for MEDLINE]
Effect of Chlorella pyrenoidosa on fecal excretion and liver accumulation of polychlorinated dibenzo-p-dioxin. Takekoshi H, Suzuki G, Chubachi H, Nakano M. Chemosphere. 2005 Apr;59(2):297-304. Epub 2005 Jan 7. PMID: 15722102 [PubMed - indexed for MEDLINE]
Nutritional supplementation with Chlorella pyrenoidosa for mild to moderate hypertension (high blood pressure). Merchant RE, Andre CA, Sica DA. J Med Food. 2002 Fall;5(3):141-52. PMID: 12495586 [PubMed - indexed for MEDLINE]
Anti-hypertensive
effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal
blood pressure and borderline hypertension
in placebo-controlled double blind study. Shimada
M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi
T. Clin Exp Hypertens. 2009 Jun;31(4):342-54.
PMID: 19811362 [PubMed - indexed for MEDLINE]
A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa shows promise in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Merchant RE, Andre CA. Altern Ther Health Med. 2001 May-Jun;7(3):79-91. Review. PMID: 11347287 [PubMed - indexed for MEDLINE]
High-yield production of lutein by the green microalgae Chlorella protothecoides in heterotrophic fed-batch culture. Shi XM, et al. Biotechnol Prog 2002;18:723-7.
Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae and Chlorella pyrenoidosa. Pugh N, et al.Planta Med 2001;67:737-42.
Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice. Hasegawa T, et al. Int J Immunopharmacol 2000;22:877-85.
Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice. Hasegawa T, et al.Int J Immunopharmacol 1999;21:311-23.
Chromate top of page
ChromeMate® Shown More Effective than Chromium Picolinate in Improving Insulin Sensitivity and Reducing Cardiovascular Disease Risk Factors Jain SK, Rains JL, Croad JL, Effect of Chromium Niacinate and Chromium Picolinate Supplementation on Lipid Peroxidation, TNF-a, IL-6, CRP, Glycated Hemoglobin, Triglycerides, and Cholesterol Levels in Blood. Free Radical Biology & Medicine43: 1124-1131 (2007).
ChromeMate® May Improve Functional Recovery of the Heart after Ischemia Bagchi D, Maulik N, Bagchi M. Niacin-bound chromium (NBC) enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/AKT/eNOS signaling pathway in diabetic myocardium. Abstract presented at Experimental Biology, April 2008, San Diego, Calif. Abs LB644.
ChromeMate® Found to Increase Life Span in Animals Preuss HG, Echard B, Bagchi D, Niacin-Bound Chromium Increases Life Span in Zucker Rats, Journal of the American College of Nutrition, 24, (5) Abs 83, 2005.
ChromeMate® Shown to Ameliorate Symptoms of Syndrome X Talpur N, Echard BW, Yasmin T, Bagchi D, and Preuss H, Effects of Niacin-Bound Chromium, Maitake Mushroom Fraction SX and (-)Hydroxycitric Acid on the Metabolic Syndrome in Aged Diabetic Zucker Fatty Rats, Molecular and Cellular Biochemistry, 252:369-377, 2003.
ChromeMate® Improves Blood Pressure, Insulin Levels and Oxidative Stress Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA, Comparative Effects of Chromium, Vanadium and Gymnema Sylvestre on Sugar-Induced Blood Pressure Elevations in SHR, Journal of the American College of Nutrition, 17:116-123, 1998.
ChromeMate® Plus Exercise Found to Reduce Weight in Obese Women Grant KE, Chandler RM, Castle AL, Ivy JL, Chromium and Exercise Training: Effect on Obese Women, Medicine & Science in Sports & Exercise, 29:992-998, 1997.
ChromeMate® Found to be More Bioavailable than Other Chromium Supplements Tested Olin KL, Stearns DM, Armstrong WH, Keen CL, Comparative Retention/Absorption of 51Chromium (51Cr) from 51Cr Chloride, 51Cr Nicotinate and 51Cr Picolinate in a Rat Model, Trace Elements and Electrolytes, 11:182-186, 1994
Long-Term Intake of OptiZinc® and ChromeMate® Reduce Oxidation, Lower Blood Pressure and Improve Blood Sugar Status Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract, and Zinc on Various Metabolic Parameters of Rats, Molecular and Cellular Biochemistry, 223:95-102, 2001
ChromeMate® and OptiZinc® Found to Reduce Signs of Aging Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract and Zinc on Various Metabolic Parameters of Rats, Molecular and Cellular Biochemistry, 223:95-102, 2001
Coral top of page
Effects of calcium sources and soluble silicate on bone metabolism and the related gene expression in mice. Maehira F, Miyagi I, Eguchi Y. Nutrition. 2009 May;25(5):581-9. Epub 2009 Jan 3. PMID: 19121918 [PubMed - indexed for MEDLINE]
The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs. Ripamonti U, Crooks J, Khoali L, Roden L. Biomaterials. 2009 Mar;30(7):1428-39. Epub 2008 Dec 9. PMID: 19081131 [PubMed - indexed for MEDLINE]
The use of Coral in bone reconstrution. Olah L, Borbas L. Acta Bioeng Biomech. 2008;10(1):61-6. PMID: 18634355 [PubMed - indexed for MEDLINE]
DGL (Deglycyrrhizinated Licorice) top of page
Deglycyrrhizinated liquorice in aphthous ulcers. Das SK, Das V, Gulati AK, Singh VP.J Assoc Physicians India. 1989 Oct;37(10):647. PMID: 2632514 [PubMed - indexed for MEDLINE]
Studies on the protective effect of deglycyrrhinised liquorice against aspirin (ASA) and ASA plus bile acid-induced gastric mucosal damage, and ASA absorption in laboratory animals Russell RI, Morgan RJ, Nelson LM. Scand J Gastroenterol Suppl. 1984;92:97-100. PMID: 6588541 [PubMed - indexed for MEDLINE]
Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium. van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J. Eur J Pharmacol. 1981 Jun 19;72(2-3):219-25. PMID: 7250207 [PubMed - indexed for MEDLINE]
EGCG (See also GreenTea) top of page
Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Britschgi A, Simon HU, Tobler A, Fey MF, Tschan MP. Br J Haematol. 2010 Jan 20. [Epub ahead of print] PMID: 20096012 [PubMed - as supplied by publisher]
Fenugreek (Trigonella foenum-graecum) top of page
Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Hamden K, Masmoudi H, Carreau S, Elfeki A. Immunopharmacol Immunotoxicol. 2010 Jan 25. [Epub ahead of print] PMID: 20100065 [PubMed - as supplied by publisher]
A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Chevassus H, Gaillard JB, Farret A, Costa F, Gabillaud I, Mas E, Dupuy AM, Michel F, Cantié C, Renard E, Galtier F, Petit P. Eur J Clin Pharmacol. 2009 Dec 18. [Epub ahead of print] PMID: 20020282 [PubMed - as supplied by publisher]
Fenugreek seeds reduce atherogenic diet-induced cholesterol gallstone formation in experimental mice. Reddy RL, Srinivasan K. Can J Physiol Pharmacol. 2009 Nov;87(11):933-43. PMID: 19935901 [PubMed - in process]
Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice. Reddy RL, Srinivasan K. Can J Physiol Pharmacol. 2009 Sep;87(9):684-93. PMID: 19794519 [PubMed - in process]
GABA (gamma-aminobutyric
acid) See also chlorella
top of page
Inhibitory role for GABA in autoimmune inflammation including multiple sclerosis Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. Proc Natl Acad Sci U S A. 2010 Feb 1. [Epub ahead of print] PMID: 20133656 [PubMed - as supplied by publisher]
Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich
Chlorella on high-normal blood pressure and borderline hypertension
in placebo-controlled double blind study. Shimada
M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi
T. Clin Exp Hypertens. 2009 Jun;31(4):342-54.
PMID: 19811362 [PubMed - indexed for MEDLINE]
Ginger Root top of page
Gingko Biloba top of page
The results on the protective effect of ginkgo biloba extract on neuron cells. Zhao B.Mol Neurobiol. 2005;31(1-3):283-93. Review. PMID: 15953828 [PubMed - indexed for MEDLINE]
Dietary supplement with a combination of Rhodiola and Ginkgo biloba enhances the endurance performance in healthy volunteers. Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Chin J Integr Med. 2009 Jun;15(3):177-83. Epub 2009 Jul 2. PMID: 19568709 [PubMed - indexed for MEDLINE]
Ginseng Korean (Panax) top of page
Therapeutic potential of Rhodiola and ginseng root preparations in treating diabetes mellitus Arushanian EB. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):52-6. Review. Russian. PMID: 20095403 [PubMed - indexed for MEDLINE]
Goji also called Wolfberry (Lycium barbarum) top of page
Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. Goji Luo Q, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ.J Med Food. 2009 Aug;12(4):695-703.
Chemoprevention of colorectal cancer-experimental and clinical aspects-. Takayama T, Goji T, Taniguchi T, Inoue A. J Med Invest. 2009 Feb;56(1-2):1-5. Review
Green TEA (See also EGCG) top of page
The promise of naturally occurring phytochemicals and green tea polyphenols for blocking early events in skin carcinogenesis. Clifford JL, Digiovanni J. Cancer Prev Res (Phila Pa). 2010 Feb;3(2):132-5. Epub 2010 Jan 26. PMID: 20103730 [PubMed - in process]
Green Tea Polyphenols Prevent UV-Induced Immunosuppression Katiyar SK, Vaid M, van Steeg H, Meeran SM. Cancer Prev Res (Phila Pa). 2010 Feb;3(2):179-89. Epub 2010 Jan 26. PMID: 20103727 [PubMed - in process]
Green Tea Extract May Treat Uterine FibroidsAn extract from green tea may be useful in treating uterine fibroids, WebMD Health News
Hawthorne Berry (Crataegus monogyna) top of page
A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels and prevention of atherosclerosis. Xu H, Xu HE, Ryan D. Am J Chin Med. 2009;37(5):903-8. PMID: 19885950 [PubMed - indexed for MEDLINE]
Free radical-scavenging activities of Crataegus monogyna extracts. Bernatoniene J, Masteikova R, Majiene D, Savickas A, Kevelaitis E, Bernatoniene R, Dvorácková K, Civinskiene G, Lekas R, Vitkevicius K, Peciura R. Medicina (Kaunas). 2008;44(9):706-12. PMID: 18971609 [PubMed - indexed for MEDLINE]
Klamath Blue Green Algae top of page
Effect of a Klamath algae product ("AFA-B12") on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study. Baroni L, Scoglio S, Benedetti S, Bonetto C, Pagliarani S, Benedetti Y, Rocchi M, Canestrari F. Int J Vitam Nutr Res. 2009 Mar;79(2):117-23. PMID: 20108213 [PubMed - in process]
Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women. Scoglio S, Benedetti S, Canino C, Santagni S, Rattighieri E, Chierchia E, Canestrari F, Genazzani AD. Gynecol Endocrinol. 2009 Apr;25(4):235-40. PMID: 19408172 [PubMed - indexed for MEDLINE]
Lactobacillus Acidophilus top of page
Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA). Karska-Wysocki B, Bazo M, Smoragiewicz W. Microbiol Res. 2010 Jan 27. [Epub ahead of print] PMID: 20116228 [PubMed - as supplied by publisher]
Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis. Cui Y, Wang CL, Liu XW, Wang XH, Chen LL, Zhao X, Fu N, Lu FG. World J Gastroenterol. 2010 Jan 28;16(4):445-52. PMID: 20101769 [PubMed - in process]
Expression profile analysis of intestinal Caco-2 cells treated with Lactobacillus acidophilus NCFM Wang M, Zhang G, Han X, Yao L, Zhou Y, Jiang Y. Wei Sheng Wu Xue Bao. 2009 Sep 4;49(9):1247-52. Chinese. PMID: 20030066 [PubMed - indexed for MEDLINE
Multistep mechanism of probiotic bacterium, the effect on innate immune system. (Inflammatory Bowel Disease Amit-Romach E, Uni Z, Reifen R. Mol Nutr Food Res. 2009 Dec 8;54(2):277-284. [Epub ahead of print] PMID: 19998380 [PubMed - as supplied by publisher]
Lactobacillus Bulgaricus top of page
Live and lyophilized Lactobacillus species elicit differential immunomodulatory effects on immune cells. Cai S, Bay BH, Lee YK, Lu J, Mahendran R. FEMS Microbiol Lett. . [Epub ahead of print] PMID: 20002187 [PubMed - as supplied by publisher]
Immunomodulation and antivirus properties of bacteria of Lactobacillus genus [No authors listed] Mikrobiol Z. 2009 May-Jun;71(3):41-7. Russian. PMID: 19938605 [PubMed - in process]
Exploring the acidotolerance of beta-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus: an attractive enzyme for lactose intolerance. Rhimi M, Aghajari N, Jaouadi B, Juy M, Boudebbouze S, Maguin E, Haser R, Bejar S. Res Microbiol. 2009 Dec;160(10):775-84. Epub 2009 Sep 26. PMID: 19786095 [PubMed - in process]
Hydrolytic breakdown of lactoferricin by lactic acid bacteria. Paul M, Somkuti GA. J Ind Microbiol Biotechnol. 2010 Feb;37(2):173-8. Epub 2009 Nov 19. PMID: 19924455 [PubMed - in process]
Lavender Oil (Lavendular angustifolia) top of page
Comparative study of the chemical composition and antioxidant activity of six essential oils and their components. Yang SA, Jeon SK, Lee EJ, Shim CH, Lee IS. Nat Prod Res. 2010;24(2):140-51. PMID: 20077307 [PubMed - in process]
Licorice Root Extract (Glycyrrhiza glabra) top of page
Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. Houssen ME, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Fathy A, Badria FA. Clin Biochem. 2010 Apr 26. [Epub ahead of print] PMID: 20430018 [PubMed - as supplied by publisher]
Mangosteen (Garcinia Mangostana) top of page
Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Doi H, Shibata MA, Shibata E, Morimoto J, Akao Y, Iinuma M, Tanigawa N, Otsuki Y. Anticancer Res. 2009 Jul;29(7):2485-95.
Potential of Xanthones from Tropical Fruit Mangosteen as Anti-cancer Agents. Watanapokasin R, Jarinthanan F, Jerusalmi A, Suksamrarn S, Nakamura Y, Sukseree S, Uthaisang-Tanethpongtamb W, Ratananukul P, Sano T. Appl Biochem Biotechnol. 2010 Jan 26. [Epub ahead of print] PMID: 20101528 [PubMed - as supplied by publisher]
Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity. Pothitirat W, Chomnawang MT, Supabphol R, Gritsanapan W. Fitoterapia. 2009 Oct;80(7):442-7. Epub 2009 Jun 12.
Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes.Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, McIntosh M J Nutr. 2009 Jun;139(6):1185-91.Epub 2009 Apr 29
Anti-cancer effects of xanthones from pericarps of mangosteen. Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Int J Mol Sci. 2008 Mar;9(3):355-70. Epub 2008 Mar 14.
The natural xanthone alpha-mangostin reduces oxidative damage in laboratory animal brain tissue. Márquez-Valadez B, Lugo-Huitrón R, Valdivia-Cerda V, Miranda-Ramírez LR, Pérez-De La Cruz V, González-Cuahutencos O, Rivero-Cruz, Mata R, Santamaría A, Pedraza-Chaverrí J. Nutr Neurosci. 2009 Feb;12(1):35-42.
Garcinia mangostana L.: a phytochemical and pharmacological review. Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Phytother Res. 2009 Aug;23(8):1047-65.
Medicinal properties of mangosteen (Garcinia mangostana). Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, Pérez-Rojas JM. Food Chem Toxicol. 2008 Oct;46(10):3227-39. Epub 2008 Aug 6. Review.
Anti-inflammatory activity of mangostins from Garcinia mangostana. Chen LG, Yang LL, Wang CC. Food Chem Toxicol. 2008 Feb;46(2):688-93. Epub 2007 Sep 26.
Oligomeric proanthocyanidins from mangosteen pericarps much higher than that of pine bark and grape seed extracts. Fu C, Loo AE, Chia FP, Huang D. J Agric Food Chem. 2007 Sep 19;55(19):7689-94. Epub 2007 Aug 23.
Antimicrobial activity in cultures of endophytic fungi isolated from Garcinia species. Phongpaichit S, Rungjindamai N, Rukachaisirikul V, Sakayaroj J. FEMS Immunol Med Microbiol. 2006 Dec;48(3):367-72. Epub 2006 Oct 18.
Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y. Bioorg Med Chem. 2004 Nov 15;12(22):5799-806.
Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. Gopalakrishnan G, Banumathi B, Suresh G. J Nat Prod. 1997 May;60(5):519-24.
Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. Planta Med. 1996 Oct;62(5):471-2.
Active constituents against HIV-1 protease from Garcinia mangostana. Chen SX, Wan M, Loh BN. Planta Med. 1996 Aug;62(4):381-2.
Antimicrobial activities of Garcinia mangostana. Sundaram BM, Gopalakrishnan C, Subramanian S, hankaranarayanan D, Kameswaran L. Planta Med. 1983 May;48(1):59-60.
Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Romier-Crouzet B, Van De Walle J, During A, Joly A, Rousseau C, Henry O, Larondelle Y, Schneider YJ. Food Chem Toxicol. 2009 Jun;47(6):1221-30. Epub 2009 Feb 20.
Maqui (Aristotelia chilensis) top of page
Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz). Escribano-Bailón MT, Alcalde-Eon C, Muñoz O, Rivas-Gonzalo JC, Santos-Buelga C. Phytochem Anal. 2006 Jan-Feb;17(1):8-14.
Antioxidant capacity of fruits and vegetables cultivated in Chile Araya H, Clavijo C, Herrera C. Arch Latinoam Nutr. 2006 Dec;56(4):361-5. Spanish.
Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease. Seeram NP. J Agric Food Chem. 2008 Feb 13;56(3):627-9. Epub 2008 Jan 23.
Muscadine Grape (Vitis rotundifolia) top of page
Heterogeneity in muscadine grape polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM. J Alzheimers Dis. 2009 Jan;16(1):59-72. PMID: 19158422 [PubMed - indexed for MEDLINE]
Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Cancer Res. 2007 Sep 1;67(17):8396-405. PMID: 17804756 [PubMed - indexed for MEDLINE]
Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects. Banini AE, Boyd LC, Allen JC, Allen HG, Sauls DL. Nutrition. 2006 Nov-Dec;22(11-12):1137-45. Epub 2006 Oct 9. PMID: 17030113 [PubMed - indexed for MEDLINE]
Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). Mertens-Talcott SU, Lee JH, Percival SS, Talcott ST. J Agric Food Chem. 2006 Jul 26;54(15):5336-43. PMID: 16848514 [PubMed - indexed for MEDLINE]
Anti-inflammatory properties of the muscadine grape (Vitis rotundifolia). Greenspan P, Bauer JD, Pollock SH, Gangemi JD, Mayer EP, Ghaffar A, Hargrove JL, Hartle DK. J Agric Food Chem. 2005 Nov 2;53(22):8481-4. PMID: 16248541 [PubMed - indexed for MEDLINE]
Opti-Zinc (See also Zinc) top of page
Summary: Zinc, like iron, copper and chromium, is one of 16 essential trace minerals the body needs to keep healthy and fit. And for people that are sick or out of shape, zinc may be the most precious metal of all. Zinc is essential for growth and development, reproduction, digestion, respiration, and for proper brain, nerve, vision and immune function. OptiZinc® is a unique, patented form of methionine-bound zinc that dramatically increase the bioavailability of zinc. Researchers have shown that OptiZinc is by far the most potent zinc antioxidant available as a dietary supplement.
Long-Term Intake of OptiZinc® and ChromeMate® Reduce Oxidation, Lower Blood Pressure and Improve Blood Sugar Status Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract, and Zinc on Various Metabolic Parameters of Rats, Molecular and Cellular Biochemistry, 223:95-102, 2001
ChromeMate® and OptiZinc® Found to Reduce Signs of Aging Source: Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D, Long-Term Effects of Chromium, Grape Seed Extract and Zinc on Various Metabolic Parameters of Rats, Molecular and Cellular Biochemistry, 223:95-102, 2001
L-OptiZinc® and OptiZinc® Significantly Reduce Oxidative Damage Source: Bagchi D, Vuchetich PJ, Bagchi M, Tran MX, Krohn RL, Ray SD, Stohs SJ, Protective Effects of Zinc Salts on TPA-Induced Hepatic and Brain Lipid Peroxidation, Glutathione Depletion, DNA Damage and Peritoneal Macrophage Activation in Mice, General Pharmacology, 30:43-50, 1998.
OptiZinc® Effective In Reducing Oxidation Source: Bagchi D, Bagchi M, Stohs SJ, Comparative In Vitro Oxygen Radical Scavenging Ability of Zinc Methionine and Selected Zinc Salts and Antioxidants, General Pharmacology, 28:85-91, 1997.
Zinc: An Essential Micronutrient Source: Bagchi D, Stohs SJ, Bagchi M. Zinc: An Essential Micronutrient and Chemoprotectant, Nutritional Perspectives: Journal of the Council on Nutrition of the American Chiropractic Association, 19:13-19, 1996.
OptiZinc® Found More Bioavailable than Other Zinc Supplements Source: Wedekind KJ, Hortin AE, Baker DH, Methodology for Assessing Zinc Bioavailability: Efficacy Estimates for Zinc-Methionine, Zinc Sulfate, and Zinc Oxide, Journal of Animal Science, 70:178-187, 1992
Papaya (Carica papaya L. Caricaceae) top of page
Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C. J Ethnopharmacol. 2009 Dec 2. [Epub ahead of print] PMID: 19961915 [PubMed - as supplied by publisher]
Carica papaya may be beneficial in ulcer. Ezike AC, Akah PA, Okoli CO, Ezeuchenne NA, Ezeugwu S. J Med Food. 2009 Dec;12(6):1268-73. PMID: 20041780 [PubMed - in process]
Thrombocyte counts in mice after the administration of papaya leaf suspension. Sathasivam K, Ramanathan S, Mansor SM, Haris MR, Wernsdorfer WH. Wien Klin Wochenschr. 2009 Oct;121 Suppl 3:19-22. PMID: 19915811 [PubMed - in process]
Phenylethylamine (PEA) top of page
SUMMARY: Phenethylamine is the ingredient in chocolate which is thought to provide the mood-elevating effects. PEA stimulates the nervous system and triggers the release of pleasurable compounds known as endorphins which supress pain and are the origin of runners high. Dietary PEA can give you the euphoric feeling of exercise without the exercise. It also potentiates the activity of dopamine, a neurochemical directly associated with sexual arousal and pleasure.Sustained antidepressant effect of PEA replacement by Sabelli H; Fink P; Fawcett J; Tom C Rush University and the Center for Creative Development, Chicago, Illinois, USA. J Neuropsychiatry Clin Neurosci, 1996 Spr, 8:2, 168-71
Phenylethylamine, a possible link to the antidepressant effects
of exercise
A Szabo, E Billett, and J Turner Br. J. Sports Med., October 1, 2001; 35(5): 342 - 343.
Combined treatment
with MAO-A inhibitor and MAO-B inhibitor increases extracellular
noradrenaline levels more than MAO-A inhibitor alone
through increases in beta-phenylethylamine. Kitaichi
Y, Inoue T, Nakagawa S, Boku S, Izumi T, Koyama T. Eur J Pharmacol.
2010 Apr 18. [Epub ahead of print]
PMID: 20406628 [PubMed - as supplied by publisher]
Pomegranate (Punica granatum L. Punicaceae) top of page
Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins. Kasimsetty SG, Bialonska D, Reddy MK, Ma G, Khan SI, Ferreira D. J Agric Food Chem. 2010 Jan 29. [Epub ahead of print] PMID: 20112993 [PubMed - as supplied by publisher]
Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Bae JY, Choi JS, Kang SW, Lee YJ, Park J, Kang YH. Exp Dermatol. 2010 Jan 25. [Epub ahead of print] PMID: 20113347 [PubMed - as supplied by publisher]
Nutraceuticals and prostate cancer prevention: a current review. Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE. Nat Rev Urol. 2010 Jan;7(1):21-30. Epub 2009 Dec 8. PMID: 19997071 [PubMed - in process]
Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. Kasimsetty SG, Bialonska D, Reddy MK, Thornton C, Willett KL, Ferreira D. J Agric Food Chem. 2009 Nov 25;57(22):10636-44. PMID: 19919114 [PubMed - in process]
Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. Growth Horm IGF Res. 2010 Feb;20(1):55-62. Epub 2009 Oct 22. PMID: 19853487 [PubMed - in process]
Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation. Grossmann ME, Mizuno NK, Schuster T, Cleary MP. Int J Oncol. 2010 Feb;36(2):421-6. PMID: 20043077 [PubMed - in process]
Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):108-13. PMID: 20051378 [PubMed - in process]
Probiotics (See also Lactotobacillus, Bifidobacterium, Streptococcus) top of page
Web MD-- Probiotics are living microorganisms -- usually “friendly” bacteria -- most often used to promote...acidophilus and Lactobacillus GG), Bifidobacteria (like Bifidobacterium bifidus) and some yeasts...WebMD Medical Reference from Medscape
Probiotics: multifarious oral vaccine against infectious traumas. Amdekar S, Dwivedi D, Roy P, Kushwah S, Singh V. FEMS Immunol Med Microbiol. 2009 Nov 6. [Epub ahead of print] PMID: 20100178 [PubMed - as supplied by publisher]
Rhodiola (Rhodiola algida) top of page
Dietary supplement with a combination of Rhodiola and Ginkgo biloba enhances the endurance performance in healthy volunteers. Zhang ZJ, Tong Y, Zou J, Chen PJ, Yu DH. Chin J Integr Med. 2009 Jun;15(3):177-83. Epub 2009 Jul 2. PMID: 19568709 [PubMed - indexed for MEDLINE]
Strong scientific evidence is available for Rhodiola rosea extract, which improved attention, cognitive function and mental performance in fatigue and in chronic fatigue syndrome Panossian A, Wikman G. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep 1. Review. PMID: 19500070 [PubMed - indexed for MEDLINE]
Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients. Loo WT, Jin LJ, Chow LW, Cheung MN, Wang M. Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S91-100. PMID: 20374035 [PubMed - in process]
A preliminary study: the anti-proliferation effect of salidroside from Rhodiola on different human cancer cell lines. Hu X, Lin S, Yu D, Qiu S, Zhang X, Mei R. Cell Biol Toxicol. 2010 Mar 23. [Epub ahead of print] PMID: 20309622 [PubMed - as supplied by publisher]
Therapeutic potential of Rhodiola and ginseng root preparations in treating diabetes mellitus Arushanian EB. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):52-6. Review. Russian. PMID: 20095403 [PubMed - indexed for MEDLINE]
Soft Drinks top of page
Soft Drink and Juice Consumption and Risk of Pancreatic Cancer: The Singapore Chinese Health Study Noel T. Mueller, Andrew Odegaard, Kristin Anderson, Jian-Min Yuan, Myron Gross, Woon-Puay Koh and Mark A. Pereira [PubMed - in process]
Spirulina top of page
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. McCarty MF. Med Hypotheses. 2010 Jan 18. [Epub ahead of print] PMID: 20089363 [PubMed - as supplied by publisher]
The prevalence, structure and clinical problems of multiple sclerosis (MS). It has been established that intake of spirulina makes for lengthening of remission in those patients with disseminated sclerosis. [Article in Ukrainian] Buletsa BA, Ihnatovych II, Lupych PP, Pulyk OR. PMID: 9138801 [PubMed - indexed for MEDLINE]
Induction of G1 cell cycle arrest and mitochondria-mediated apoptosis in MCF-7 human breast carcinoma cells by selenium-enriched Spirulina extract. Chen T, Wong YS, Zheng W. Biomed Pharmacother. 2009 Oct 27. [Epub ahead of print] PMID: 19926246 [PubMed - as supplied by publisher]
Inhibitory effects of polysaccharide extract from Spirulina platensis on corneal neovascularization. Yang L, Wang Y, Zhou Q, Chen P, Wang Y, Wang Y, Liu T, Xie L. Mol Vis. 2009 Sep 24;15:1951-61. PMID: 19784394 [PubMed - indexed for MEDLINE]
Alterations in beta-islets of Langerhans in alloxan-induced diabetic laboratory animals by marine Spirulina platensis. Muthuraman P, Senthilkumar R, Srikumar K. J Enzyme Inhib Med Chem. 2009 Apr 28. [Epub ahead of print] PMID: 19555165 [PubMed - as supplied by publisher]
Chemoprevention of liver toxicity and carcinogenesis by Spirulina. Ismail MF, Ali DA, Fernando A, Abdraboh ME, Gaur RL, Ibrahim WM, Raj MH, Ouhtit A. Int J Biol Sci. 2009 Jun 2;5(4):377-87. PMID: 19521547 [PubMed - indexed for MEDLINE]
Streptococcus thermophilus top of page
Multistep mechanism of probiotic bacterium, the effect on innate immune system. (Inflammatory Bowel Disease Amit-Romach E, Uni Z, Reifen R. Mol Nutr Food Res. 2009 Dec 8;54(2):277-284. [Epub ahead of print] PMID: 19998380 [PubMed - as supplied by publisher]
Hydrolytic breakdown of lactoferricin by lactic acid bacteria. Paul M, Somkuti GA. J Ind Microbiol Biotechnol. 2010 Feb;37(2):173-8. Epub 2009 Nov 19. PMID: 19924455 [PubMed - in process]
Emergence of a cell wall protease in the Streptococcus thermophilus population. Delorme C, Bartholini C, Bolotine A, Ehrlich SD, Renault P. Appl Environ Microbiol. 2010 Jan;76(2):451-60. Epub 2009 Nov 13. PMID: 19915034 [PubMed - in process]
Taurine top of page
Taurine improves learning and retention in aged mice. El Idrissi A. Neurosci Lett. 2008 May 2;436(1):19-22. Epub 2008 Mar 7. PMID: 18375059 [PubMed - indexed for MEDLINE]
Taurine deficiency in thalassemia major-induced osteoporosis treated with neridronate. D'Eufemia P, Finocchiaro R, Celli M, Raccio I, Zambrano A, Tetti M, Smacchia P, Iacobini M. Biomed Pharmacother. 2010 Apr;64(4):271-4. Epub 2009 Oct 23. PMID: 20359847 [PubMed - in process]
Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy. Askwith T, Zeng W, Eggo MC, Stevens MJ. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E620-8. Epub 2009 Jul 14. PMID: 19602579 [PubMed - indexed for MEDLINE]
Wolfberry (See Goji) top of page
Yerba Maté (Ilex paraguayensis St-Hil) top of page
Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of Yerba Maté Ranilla LG, Kwon YI, Apostolidis E, Shetty K. Bioresour Technol. 2010 Jun;101(12):4676-89. Epub 2010 Feb 25. PMID: 20185303 [PubMed - in process]
Xanthones (See Mangosteen) top of page
Zinc (See also Opti-Zinc) top of page
How does zinc supplementation benefit anorexia nervosa? Birmingham CL, Gritzner S. Eat Weight Disord. 2006 Dec;11(4):e109-11. PMID: 17272939 [PubMed - indexed for MEDLINE]